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Porphyria cutanea tarda (Porphyria cutanea tarda) is one of common type of porphyria was found, causing blisters on sun-exposed skin.
porphyria cutanea tarda CAUSE
Porphyria cutanea tarda occurs worldwide and it is the only real form of non-hereditary porphyria (hereditary diseases).
This disease is a hepatic porphyria, occurs when uroporphyrinogen decarboxylase (among the enzymes inside the liver that is very important to the development of heme), become inactive.
Contributing factor just for this disease are:
- Iron
- Alcohol
- Estrogen
- Hepatitis C viral infection
Porphyria cutanea tarda sometimes is situated people who are infected by HIV.
Even though disease is not inherited, sometimes uroporphyrinogen decarboxylase enzyme deficiency that's partial, inherited by one of many parents and make up a person more at risk from have problems with this complaint.
Such cases are known as familial porphyria cutanea tarda.
porphyria cutanea tarda symptoms
Skin blisters occur on sun-exposed areas, for example the back of the hands, arms and face.
Skin, especially the skin from the hands, incredibly responsive to trauma.
Is going to be and then skin blisters scab and scar tissue formation formation, that takes a while to the healing process.
Scarring damage occurs as a consequence of porphyrin produced in the liver was transferred by skin towards the blood plasma.
A rise in new hair growth on the face.
Liver usually is slightly damaged caused by hepatitis C virus infection or due to excessive drinking.
Before too long, it may happen cirrhosis and in some cases liver cancer.
porphyria cutanea tarda diagnosis
To manufacture a proper diagnosis of porphyria cutanea tarda, study of plasma, urine and feces to the chance of porphyrins.
Porphyria which causes lesions (sores) within the skin accompanied by high degrees of porphyrins inside blood plasma.
At porphyria cutanea tarda, numbers of porphyrins from the urine and feces also increased.
porphyria cutanea tarda treatment
Porphyria porphyria cutanea tarda is regarded as the easily treated.
Performed an activity called phlebotomi, of which approximately 0.5 L of blood were taken every 1-2 weeks.
Phlebotomi can make the person experienced mild iron deficiency.
Porphyrin levels in liver and plasm will decrease gradually, your skin layer will improve and ultimately become normal again.
Phlebotomi usually done only 5-6 times; anemia will occur when too often done phlebotomi.
If the disease relapses, ought to be practiced [additional hlebotomi.
Chloroquine or hidroklorokuin also effective in small doses.
Drugs is generating excess porphyrins from the liver.
Though the doses are far too high allowing the porphyrin spending too fast, so at the moment is usually worsened pofiria cutanea tarda and liver damage.
Avoiding alcohol can help accelerate healing.
