THE HUNTINGTON DISEASE

HUNTINGTON DISEASE SYMPTOMS

THE HUNTINGTON DISEASE

A. DEFINITIONS

Ø Name of the disease is taken from the first George Huntington first described the tahun1872.

Ø Huntington's disease (Huntington korea) is a hereditary disease in which the jerk or spasm and loss of brain cells gradually begin to appear in middle age and develop into Korean, atetosis and mental deterioration.

Ø Huntington's disease is a neurodegenerative genetic disorder that affects muscle coordination and causes a decrease in muscle and dementia (dementia), which is slowly but surely lead to death. Huntington chorea disease

B. RISK FACTORS

Each child of an affected parent has a 50% chance of inheriting penyakit.Pada rare situations where both parents have an affected gene, or either parent has two affected copies, this chance is greatly increased.

C. Etiology

The gene for Huntington's disease is dominant children of parents who suffer from this disease have a 50% chance of developing Huntington's disease.

This is the most common genetic cause of abnormal involuntary writhing movements called chorea. It is much more common in people of Western European descent than in those from Asia or Africa. The disease is caused by a dominant mutation in one of two copies of a particular gene, located on chromosome 4. In the rare situations where both parents have the affected gene, or either parent has two affected copies, this chance is greatly increased.

Huntingtin gene normally provides the genetic code for a protein that is also called "huntingtin". Mutation of the Huntingtin gene codes for a different form of the protein, whose presence resulted in gradual damage to specific regions of the brain. The proper way this occurs is not fully understood. THE HUNTINGTON DISEASE

SIGNS AND SYMPTOMS
a. In the early stages of this disease, abnormal movements mixed with moves being made by the patient so that the abnormal movement is hardly noticed. But gradually it became clear abnormal movements.
Ultimately abnormal movements that occur will affect the entire body so that it is almost impossible conducting patient eating, dressing and even sat in silence.
b. Mental changes initially vague. Patients gradually become irritable and easily excited, they may lose interest in daily activities.
c. Subsequently the patient became irresponsible and often travel without a definite purpose.
d. Patients lose control over his desires and become promiscuous (having sexual relations with anyone.
e. Years later, the patient will lose his memory and lost his ability to think rationally.
f. Patients experiencing severe depression and suicide attempts.
g. In later stages, almost all patients have impaired function and patients need help from others to carry out its functions.
Death is often triggered by pneumonia or a fall, which usually occurs 13-15 years after the onset of the first symptoms.
Other signs and symptoms that may appear:
v Physical Symptoms

•  involuntary movements of the fingers, feet, and face.
•  awkwardness
•  Loss of balance or coordination.
•  Lisp speech
• pengiling Clenching the jaw or teeth.
•  Difficulty eating.
•  Stumbling or falling

v Mental Symptoms

• Forgetfulness
•  Loss of concentration
• Assessment bad
• Difficulty in making decisions
•  Difficulty driving
•  Emotional Symptoms
•  Hostilities
• Lack of energy
•  Interest in life
•  Depression

On the further development of this disease can cause hallucinations, aggression without reason, and paranoia.